“There is indeed one quest currently in the game where a Jewel of Fortune can, in some circumstances, prevent you from getting treasure. If affected by this, the chest will be completely empty for you- nothing at all will appear in it.
“This can only happen in “The Reaver’s Fate”, which is the Heroic-tier raid in Gianthold. This does not happen in the Epic Gianthold raid, or any other quests in the game.
“This issue is fixed in the next upcoming patch to DDO, Update 18.”
Since it only effects one quest it doesn’t seem too bad of a bug but it’s gotta suck tremendously if you’re unaware of this and have the Jewel running and get an empty chest in a raid.